Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Natural YMDD motif mutations of HBV polymerase in the chronic hepatitis B virus infected patients].

Taehan Kan Hakhoe chi = The Korean journal of hepatology - 1 Mar 2003

Shin Young Min, Heo Jeong, Kim Gwang Ha, Kang Dae Hwan, Song Geun Am, Cho Mong, Yang Ung Suk, Kim Cheol Min, Park Hee Kyung, Jang Hyun Jung

Abstract excerpt

BACKGROUND/AIMS: Lamivudine, a nucleoside analogue has been widely used as an effective antiviral agent for the treatment of patients with chronic hepatitis B infection. However, the YMDD motif mutation of HBV polymerase resistant to lamivudine very frequently occurs after long-term use of lamivudine. It is well known that the mutation is selected by the lamivudine. We hypothesized that a few mutant strains of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, pol

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Mutation

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 12657823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Natural YMDD motif mutations of HBV polymerase in the chronic hepatitis B virus infected patients].PMID 12657823Read ↗

Rate of YMDD motif mutants in lamivudine-untreated Iranian patients with chronic hepatitis B virus infection.Semantic proximity Read ↗

Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine.Semantic proximity Read ↗

Evolution of wild type and mutants of the YMDD motif of hepatitis B virus polymerase during lamivudine therapy.Semantic proximity Read ↗

[Types and emergence time of YMDD motif mutation in hepatitis B virus polymerase gene during lamivudine treatment].Semantic proximity Read ↗

Detection of YMDD motif mutations in some lamivudine-untreated asymptomatic hepatitis B virus carriers.Semantic proximity Read ↗

[A study on the mutation of P gene region including YMDD motif in hepatitis B virus].Semantic proximity Read ↗

The naturally occurring YMDD mutation among patients chronically infected HBV and untreated with lamivudine: a systematic review and meta-analysis.Semantic proximity Read ↗

[Efficacy changes of short-term lamivudine therapy for chronic hepatitis B with emergence of YMDD mutation].Semantic proximity Read ↗

[Detection of YMDD motif mutations in lamivudine-untreated patients with chronic hepatitis B].Semantic proximity Read ↗

[Identification of factors associated with YMDD mutation in patients with chronic hepatitis B receiving lamivudine treatment].Semantic proximity Read ↗

[Occurrence and predictive factors of hepatitis B virus polymerase YMDD variation among patients with chronic hepatitis B and liver cirrhosis during lamivudine therapy].Semantic proximity Read ↗

Prevelance of common YMDD motif mutations in long term treated chronic HBV infections in a Turkish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.