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Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases

30 Aug 2018

Abstract excerpt

Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6. The biological functions of IGFBPs can be classified as IGFs-dependent actions and IGFs-independent effects. In this review, we will discuss the structure and function of various IGFBPs, particularly IGFBPs as potential...

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PMID: 30214426
DOI: 10.3389/fendo.2018.00499

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