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Article

Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice.

The Journal of biological chemistry - 27 Aug 2010

Mall Marcus A, Button Brian, Johannesson Bjarki, Zhou Zhe, Livraghi Alessandra, Caldwell Ray A, Schubert Susanne C, Schultz Carsten, O'Neal Wanda K, Pradervand Sylvain, Hummler Edith, Rossier Bernard C, Grubb Barbara R, Boucher Richard C

Abstract excerpt

Studies in cystic fibrosis patients and mice overexpressing the epithelial Na(+) channel beta-subunit (betaENaC-Tg) suggest that raised airway Na(+) transport and airway surface liquid (ASL) depletion are central to the pathogenesis of cystic fibrosis lung disease. However, patients or mice with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20566636
DOI: 10.1074/jbc.M110.151803
PMCID: PMC2930694

Genes

ASL
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20566636-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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