Article
Genetic and enzymatic characterization of 3-O-sulfotransferase SNPs associated with Plasmodium falciparum parasitaemia.
Glycobiology - 1 Jul 2018
Nguyen Ngoc Thy, Vivès Romain R, Torres Magali, Delauzun Vincent, Saesen Els, Roig-Zamboni Véronique, Lortat-Jacob Hugues, Rihet Pascal, Bourne Yves
Abstract excerpt
The HS3ST3A1/B1 genes encode two homologous 3-O-sulfotransferases involved in the late modification step during heparan sulfate (HS) biosynthesis. In addition to the single nucleotide polymorphisms (SNPs) rs28470223 (C > T) in the promoter region of both HS3ST3A1 and rs62636623 (Gly/Arg) in the stem region of HS3ST3B1, three missense mutations (rs62056073, rs61729712 and rs9906590) located within the catalytic...