Differential Sensitivity of Human Neuroblastoma Cell Lines to Ethanol: Correlations with Their Proliferative Responses to Mitogenic Growth Factors and Expression of Growth Factor Receptors

Abstract excerpt

Early ethanol exposure depletes neurons in the developing nervous system, however the effects on neuronal precursors are not homogeneous. Some cells are more susceptible to ethanol toxicity than others. Growth factors are important mitogens for neuronal precursors. We tested the hypothesis that the differential sensitivity of neuronal precursors to ethanol is determined by their responses to growth factors using...

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