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Article

Possible gene dosage effect of glutathione-S-transferases on atopic asthma: using real-time PCR for quantification of GSTM1 and GSTT1 gene copy numbers.

Human mutation - 1 Sept 2004

Brasch-Andersen Charlotte, Christiansen Lene, Tan Qihua, Haagerup Annette, Vestbo Jørgen, Kruse Torben A

Abstract excerpt

Asthma is a complex genetic disorder characterized by chronic inflammation in the airways. As oxidative stress is a key component of inflammation, variations in genes involved in antioxidant defense could therefore be likely candidates for asthma. Three enzymes from the superfamily glutathione-S-transferase (GST) involved in the antioxidant defense were tested for association to asthma using 246 Danish atopic...

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Source

Identifiers

PMID: 15300848
DOI: 10.1002/humu.20074

Genes

GSTT1
GSTM1
GSTP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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