Article
Contribution of oligosaccharides to protection of the H,K-ATPase beta-subunit against trypsinolysis.
Electrophoresis - 1 Aug 2004
Crothers James M, Asano Shinji, Kimura Tohru, Yoshida Ayumi, Wong Aline, Kang Jung Wook, Forte John G
Abstract excerpt
The proton-pumping H+,K+-adenosinetriphosphatase (H,K-ATPase), responsible for acid secretion by the gastric parietal cell, faces a harshly acidic environment, with some pepsin from neighboring chief cells, at its luminal surface. Its large catalytic alpha-subunit is mostly oriented cytoplasmically. The smaller beta-subunit (HKbeta), is mainly extracellular, with one transmembrane domain and a small cytoplasmic...
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