Article
Unmasking a new recognition signal for O-linked glycosylation in the chorionic gonadotropin beta subunit.
Molecular and cellular endocrinology - 30 Aug 2002
Garcia-Campayo Vicenta, Sugahara Tadashi, Boime Irving
Abstract excerpt
hCGbeta subunit is distinguished among the other members of the family of the glycoprotein hormones by the presence of four serine O-linked oligosaccharide units in the last 25 amino acids. This carboxy terminal peptide (CTP) influences the intracellular behavior of the subunit and is important for maintaining the biological half-life of hCG. To examine how the O-linked oligosaccharides affect the metabolic...
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