Article
The phosphorylation of bovine DNase I Asn-linked oligosaccharides is dependent on specific lysine and arginine residues.
The Journal of biological chemistry - 1 Aug 1997
Nishikawa A, Gregory W, Frenz J, Cacia J, Kornfeld S
Abstract excerpt
The secretory glycoprotein DNase I acquires mannose 6-phosphate moieties on its Asn-linked oligosaccharides, indicating that it is a substrate for UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (phosphotransferase) (Cacia, J., Quan, C., and Frenz, J. (1995) Glycobiology 4, 99). Phosphotransferase recognizes a conformation-dependent protein determinant that is present in lysosomal hydrolases,...
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