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Article

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.

Science (New York, N.Y.) - 6 Aug 2004

Nettles James H, Li Huilin, Cornett Ben, Krahn Joseph M, Snyder James P, Downing Kenneth H

Abstract excerpt

The structure of epothilone A, bound to alpha,beta-tubulin in zinc-stabilized sheets, was determined by a combination of electron crystallography at 2.89 angstrom resolution and nuclear magnetic resonance-based conformational analysis. The complex explains both the broad-based epothilone structure-activity relationship and the known mutational resistance profile. Comparison with Taxol shows that the longstanding...

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Identifiers

PMID: 15297674
DOI: 10.1126/science.1099190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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