Article
Mutations in beta-tubulin map to domains involved in regulation of microtubule stability in epothilone-resistant cell lines.
Molecular cancer therapeutics - 1 Nov 2001
He L, Yang C P, Horwitz S B
Abstract excerpt
The epothilones (Epos) are a group of natural products isolated from the myxobacterium, Sorangium cellulosum. They have a mechanism of action similar to that of Taxol, i.e., they stabilize microtubules and induce the formation of microtubule bundles in cells. Because they are simpler in structure...
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