Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.

Angewandte Chemie (International ed. in English) - 18 Feb 2005

Heinz Dirk W, Schubert Wolf-Dieter, Höfle Gerhard

Abstract excerpt

No abstract is available from the source.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallography
Share to Cytochrome P-450 Enzyme System
Share to Microtubules
Share to Molecular Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Structure

Share to Oxidoreductases

Share to Paclitaxel

Share to Tubulin

Source

Identifiers

PMID: 15714588
DOI: 10.1002/anie.200462241

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.PMID 15714588Read ↗

The biology and medicinal chemistry of epothilones.Semantic proximity Read ↗

Structural insight into the mechanism of epothilone A bound to beta-tubulin and its mutants at Arg282Gln and Thr274Ile.Semantic proximity Read ↗

Epothilone B and its Analogs - A New Family of Anticancer AgentsSemantic proximity Read ↗

Structural basis for drug resistance conferred by β-tubulin mutations: a molecular modeling study on native and mutated tubulin complexes with epothilone B.Semantic proximity Read ↗

The clinical development of new mitotic inhibitors that stabilize the microtubuleSemantic proximity Read ↗

Novel Drugs Targeting Microtubules: the Role of EpothilonesSemantic proximity Read ↗

Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune diseaseSemantic proximity Read ↗

Computational Approaches to the Rational Design of Tubulin-Targeting AgentsSemantic proximity Read ↗

Epothilones: Mechanism of Action and Biologic ActivitySemantic proximity Read ↗

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.Semantic proximity Read ↗

A Structure-Guided Approach to Creating Covalent FGFR InhibitorsSemantic proximity Read ↗

The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin DegradationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.