Article
Defective mismatch repair and the development of recurrent endometrial carcinoma.
Gynecologic oncology - 1 Aug 2004
Pijnenborg J M A, Dam-de Veen G C, de Haan J, van Engeland M, Groothuis P G
Abstract excerpt
OBJECTIVE: To investigate whether defective DNA mismatch repair (MMR) defines a subgroup at risk for recurrence in sporadic endometrial carcinoma patients. METHODS: Primary tumors from 44 patients with recurrent stage I endometrial carcinoma were compared after matching, with tumors of 44 patients being free of recurrence for minimal 3 years. Paraffin-embedded primary tumors (n = 88) and recurrent tumors (n = 32)...
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