Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The High Frequency of De novo Promoter Methylation in Synchronous Primary Endometrial and Ovarian Carcinomas

1 Jun 2006

Abstract excerpt

PURPOSE: The methylation status of hMLH1, CDKN2A, and MGMT was investigated in a panel of synchronous cancers of the ovary and endometrium, fulfilling the clinicopathologic criteria for independent primary tumors to define the possible role of epigenetic mechanisms in the development of these cancers. EXPERIMENTAL DESIGN: Bisulfite-converted DNA from 31 tumors (13 endometrial and 18 ovarian carcinomas) and from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to Epigenetics and DNA Methylation
Share to Ovarian cancer diagnosis and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16740754
DOI: 10.1158/1078-0432.ccr-05-2679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The High Frequency of De novo Promoter Methylation in Synchronous Primary Endometrial and Ovarian CarcinomasPMID 16740754Read ↗

MLH1/PMS2-deficient Endometrial Carcinomas in a Universally Screened Population: MLH1 Hypermethylation and Germline Mutation StatusSemantic proximity Read ↗

Women With Synchronous Primary Cancers of the Endometrium and Ovary: Do They Have Lynch Syndrome?Semantic proximity Read ↗

hMLH1 Promoter Hypermethylation Is an Early Event in Human Endometrial TumorigenesisSemantic proximity Read ↗

Defective mismatch repair and the development of recurrent endometrial carcinoma.Semantic proximity Read ↗

Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation.Semantic proximity Read ↗

Clinicopathological significance of deficient DNA mismatch repair and MLH1 promoter methylation in endometrioid endometrial carcinomaSemantic proximity Read ↗

Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological dataSemantic proximity Read ↗

MLH1 Promoter Methylation Could Be the Second Hit in Lynch Syndrome Carcinogenesis.Semantic proximity Read ↗

Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers.Semantic proximity Read ↗

hMLH1 promoter hypermethylation and MSI status in human endometrial carcinomas with and without metastases.Semantic proximity Read ↗

High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas.Semantic proximity Read ↗

Mutually Exclusive Promoter Hypermethylation Patterns of hMLH1 and O-Methylguanine DNA Methyltransferase in Colorectal CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.