Article

Lyophilized Cell-Secreted Matrix as a Bioactive Substrate for Chondrocyte Expansion and Redifferentiation

2026-02-16

Abstract excerpt

Articular cartilage repair is limited by the poor regenerative capacity of chondrocytes and their rapid dedifferentiation during in vitro expansion. This study investigated whether a decellularized and lyophilized cell-secreted matrix (CSM) could function as a bioactive material to regulate cell behavior, promote chondrogenic differentiation, and attenuate or reverse chondrocyte dedifferentiation without exogenous...

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Literature Corpus work: 3d7a1c92-f675-56ca-a90f-850c20ed0a10
DOI: 10.64898/2026.02.13.705752

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