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Article

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

Progress in neurobiology - 1 May 2008

Turner Bradley J, Talbot Kevin

Abstract excerpt

Gain-of-function mutations in the Cu,Zn-superoxide dismutase (SOD1) gene are implicated in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral sclerosis (ALS). At present, transgenic expression of 12 human SOD1 mutations driven by the endogenous promoter is disease-causative and uniformly lethal in mice and rats, despite tremendous biochemical and biophysical variation...

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Source

Identifiers

PMID: 18282652
DOI: 10.1016/j.pneurobio.2008.01.001

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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