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Article

Evolution of the human ABO polymorphism by two complementary selective pressures

19 Apr 2004

Abstract excerpt

The best-known example of terminal-glycan variation is the ABO histo-blood group polymorphism in humans. We model two selective forces acting on histo-blood group antigens that may account for this polymorphism. The first is generated by the invasion of opportunistic bacterial or other pathogens that interact with the epithelial-mucosal surfaces. The bacteria adapt to the microenvironments of common host...

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PMID: 15293861
DOI: 10.1098/rspb.2004.2674

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