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Article

Balanced polymorphism selected by genetic versus infectious human disease.

Annual review of genomics and human genetics - 1 Jan 2002

Dean Michael, Carrington Mary, O'Brien Stephen J

Abstract excerpt

The polymorphisms within the human genome include several functional variants that cause debilitating inherited diseases. An elevated frequency of some of these deleterious mutations can be explained by a beneficial effect that confers a selective advantage owing to disease resistance in carriers of such mutations during an infectious disease outbreak. We here review plausible examples of balanced functional...

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Identifiers

PMID: 12142357
DOI: 10.1146/annurev.genom.3.022502.103149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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