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Article

A General Model of Negative Frequency Dependent Selection Explains Global Patterns of Human ABO Polymorphism.

PloS one - 1 Jan 2015

Villanea Fernando A, Safi Kristin N, Busch Jeremiah W

Abstract excerpt

The ABO locus in humans is characterized by elevated heterozygosity and very similar allele frequencies among populations scattered across the globe. Using knowledge of ABO protein function, we generated a simple model of asymmetric negative frequency dependent selection and genetic drift to explain the maintenance of ABO polymorphism and its loss in human populations. In our models, regardless of the strength of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25946124
DOI: 10.1371/journal.pone.0125003
PMCID: PMC4422588

Genes

ABO

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