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Article

Ancestry runs deeper than blood: the evolutionary history of ABO points to cryptic variation of functional importance.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Oct 2013

Ségurel Laure, Gao Ziyue, Przeworski Molly

Abstract excerpt

The ABO histo-blood group, first discovered over a century ago, is found not only in humans but also in many other primate species, with the same genetic variants maintained for at least 20 million years. Polymorphisms in ABO have been associated with susceptibility to a large number of human diseases, from gastric cancers to immune or artery diseases, but the adaptive phenotypes to which the polymorphism...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23836453
DOI: 10.1002/bies.201300030
PMCID: PMC4034584

Genes

ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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