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Article

Cardiolipin biosynthesis and mitochondrial respiratory chain function are interdependent.

The Journal of biological chemistry - 8 Oct 2004

Gohil Vishal M, Hayes Paulette, Matsuyama Shigemi, Schägger Hermann, Schlame Michael, Greenberg Miriam L

Abstract excerpt

Cardiolipin (CL) is an acidic phospholipid present almost exclusively in membranes harboring respiratory chain complexes. We have previously shown that, in Saccharomyces cerevisiae, CL provides stability to respiratory chain supercomplexes and CL synthase enzyme activity is reduced in several respiratory complex assembly mutants. In the current study, we investigated the interdependence of the mitochondrial...

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Identifiers

PMID: 15292198
DOI: 10.1074/jbc.M402545200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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