Article
Cardiolipin molecular species with shorter acyl chains accumulate in Saccharomyces cerevisiae mutants lacking the acyl coenzyme A-binding protein Acb1p: new insights into acyl chain remodeling of cardiolipin.
The Journal of biological chemistry - 2 Oct 2009
Rijken Pieter J, Houtkooper Riekelt H, Akbari Hana, Brouwers Jos F, Koorengevel Martijn C, de Kruijff Ben, Frentzen Margrit, Vaz Frédéric M, de Kroon Anton I P M
Abstract excerpt
The function of the mitochondrial phospholipid cardiolipin (CL) is thought to depend on its acyl chain composition. The present study aims at a better understanding of the way the CL species profile is established in Saccharomyces cerevisiae by using depletion of the acyl-CoA-binding protein Acb1p as a tool to modulate the cellular acyl chain content. Despite the presence of an intact CL remodeling system, acyl...
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