E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients.

doi:10.1016/j.ejca.2004.04.027

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Article

E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients.

European journal of cancer (Oxford, England : 1990) - 1 Aug 2004

Oliveira Carla, Ferreira Paulo, Nabais Sérgio, Campos Luisa, Ferreira Ana, Cirnes Luís, Alves Catarina Castro, Veiga Isabel, Fragoso Maria, Regateiro Fernando, Dias Luis Moreira, Moreira Herculano, Suriano Gianpaolo, Machado José Carlos, Lopes Carlos, Castedo Sérgio, Carneiro Fátima, Seruca Raquel

Abstract excerpt

Approximately 30% of all hereditary diffuse gastric cancer (HDGC) families carry CDH1 germline mutations. The other two thirds remain genetically unexplained and are probably caused by alterations in other genes. Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)...

Topics

Adult
Cadherins
Caspase 10
Caspases
DNA-Binding Proteins
Female
Genes, p53
Genetic Predisposition to Disease
Germ-Line Mutation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microsatellite Repeats

Middle Aged

Pedigree

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Portugal

Smad4 Protein

Source

Open in PubMed

Identifiers

PMID: 15288293
DOI: 10.1016/j.ejca.2004.04.027

Genes

CDH1
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15288293-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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