E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients.

doi:10.1016/j.ejca.2004.04.027

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Article

E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients.

European journal of cancer (Oxford, England : 1990) - 1 Aug 2004

Oliveira Carla, Ferreira Paulo, Nabais Sérgio, Campos Luisa, Ferreira Ana, Cirnes Luís, Alves Catarina Castro, Veiga Isabel, Fragoso Maria, Regateiro Fernando, Dias Luis Moreira, Moreira Herculano, Suriano Gianpaolo, Machado José Carlos, Lopes Carlos, Castedo Sérgio, Carneiro Fátima, Seruca Raquel

Abstract excerpt

Approximately 30% of all hereditary diffuse gastric cancer (HDGC) families carry CDH1 germline mutations. The other two thirds remain genetically unexplained and are probably caused by alterations in other genes. Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)/sequencing, we screened 32 Portuguese families with a history of gastric cancer and 23 patients with early onset...

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Identifiers

PMID: 15288293
DOI: 10.1016/j.ejca.2004.04.027

Genes

CDH1
SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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