Article
Polymorphisms in interleukin-1 beta and Interleukin-1 receptor antagonist genes are associated with kidney failure in Korean patients with type 2 diabetes mellitus.
American journal of nephrology - 1 Jan 2000
Lee Sang Ho, Ihm Chun-Gyoo, Sohn Seong Dong, Lee Tae Won, Kim Myung Jae, Koh Gwanpyo, Oh Seung Joon, Woo Jeoung-Taek, Kim Sung Woon, Kim Jin Woo, Kim Young Seol, Lee Byung Cheol, Kim Seong Do, Cho Byoung Soo, Lee Hee-Jae, Chung Joo-Ho
Abstract excerpt
BACKGROUND/AIM: Cytokines play an important role in the pathogenesis of kidney diseases. The aim of the study was to investigate the impact of interleukin (IL)-1 cluster genes on diabetic nephropathy in Korean patients with type 2 diabetes mellitus (DM). METHODS: We investigated -511 C/T polymorphism of IL-1 beta and tandem repeat polymorphism in intron 2 of IL-1 receptor antagonist in type 2 DM patients with...
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