Article
Impact of IL2 and IL2RB genetic polymorphisms in kidney transplantation.
Transplantation proceedings - 1 Jan 2000
Park S J, Yoon Y C, Kang S W, Kim T H, Kim Y W, Joo H, Kim H J, Jeong K H, Lee D Y, Lee S S, Chung J H, Kim Y H
Abstract excerpt
Patient genetic make-up may contribute to a higher risk for acute rejection episodes (AREs). Because interleukin-2 (IL2) and IL2 receptor β (IL2RB) play key roles in immune modulation, we investigated the effect of single-nucleotide polymorphisms (SNPs) in the IL2 gene (rs2069762; T>G, promoter; and rs2069763; G>T, exon 1, Leu38Leu) and IL2RB gene (rs228942: C>A, exon 1, Asp391Glu; and rs228953: C>T, exon 8,...
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