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Telomeres, telomerase, and apoptosis

1 Aug 2004

Abstract excerpt

Telomeres are specialized high-order chromatin structures that cap the ends of eukaryotic chromosomes. In vertebrates, telomeric DNA is composed of repetitions of the TTAGGG hexanucleotide, is bound to a set of specific proteins, and is elongated by the reverse transcriptase enzyme telomerase. Telomerase activity is promptly detected in cells with an indefinite replicative potential, such as cancer cells, while...

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PMID: 15284903
DOI: 10.1139/o04-048

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