Article
Telomeres and telomerase.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2004
Chan Simon R W L, Blackburn Elizabeth H
Abstract excerpt
Telomeres are the protective DNA-protein complexes found at the ends of eukaryotic chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G-rich, sequence specified by the action of telomerase, and complete replication of telomeric DNA requires telomerase. Telomerase is a specialized cellular ribonucleoprotein reverse transcriptase. By copying a short template sequence within its intrinsic RNA...
Topics
- DNA Damage
- DNA Replication
- DNA-Binding Proteins
- Evolution, Molecular
- Gene Library
- Models, Genetic
- Mutation
- RNA
- Telomerase
- Telomere