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Primer design and marker clustering for multiplex SNP-IT primer extension genotyping assay using statistical modeling.

Bioinformatics (Oxford, England) - 12 Dec 2004

Yuryev Anton, Huang Jianping, Scott Kathryn E, Kuebler Jennifer, Donaldson Miriam, Phillips Michael S, Pohl Mark, Boyce-Jacino Michael T

Abstract excerpt

MOTIVATION: The optimization of the primer design is critical for the development of high-throughput SNP genotyping methods. Recently developed statistical models of the SNP-IT primer extension genotyping reaction allow further improvement of primer quality for the assay. RESULTS: Here we describe how the statistical models can be used to improve primer design for the assay. We also show how to optimize...

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PMID: 15284101
DOI: 10.1093/bioinformatics/bth439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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