Article
Computational tradeoffs in multiplex PCR assay design for SNP genotyping.
BMC genomics - 25 Jul 2005
Rachlin John, Ding Chunming, Cantor Charles, Kasif Simon
Abstract excerpt
BACKGROUND: Multiplex PCR is a key technology for detecting infectious microorganisms, whole-genome sequencing, forensic analysis, and for enabling flexible yet low-cost genotyping. However, the design of a multiplex PCR assays requires the consideration of multiple competing objectives and physical constraints, and extensive computational analysis must be performed in order to identify the possible formation of...
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