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Article

R753Q single-nucleotide polymorphism impairs toll-like receptor 2 recognition of hepatitis C virus core and nonstructural 3 proteins.

Transplantation - 15 Apr 2010

Brown Robert A, Gralewski Jonathon H, Eid Albert J, Knoll Bettina M, Finberg Robert W, Razonable Raymund R

Abstract excerpt

BACKGROUND: Hepatitis C virus (HCV) core and nonstructural (NS) 3 proteins induce inflammation and immunity through a toll-like receptor (TLR) 2-dependent pathway. Individuals with the R753Q single-nucleotide polymorphism (SNP) in the TLR2 gene have increased the risk of allograft failure after l...

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Source

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Identifiers

PMID: 20090572
DOI: 10.1097/TP.0b013e3181cbac18
PMCID: PMC2857328

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20090572-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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