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Article

Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum.

PloS one - 1 Jan 2017

Gupta Himanshu, Chaudhari Sima, Rai Ayushi, Bhat Smitha, Sahu Pratima K, Hande Manjunath H, D'Souza Sydney C, Shashikiran Umakanth, Satyamoorthy Kapaettu

Abstract excerpt

Multiple mechanisms such as genetic and epigenetic variations within a key gene may play a role in malarial susceptibility and response to anti-malarial drugs in the population. ABCB1 is one of the well-studied membrane transporter genes that code for the P-glycoprotein (an efflux protein) and whose effect on malaria disease predisposition and susceptibility to drugs remains to be understood. We studied the...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Host-Parasite Interactions

Share to Malaria, Falciparum

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Source

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Identifiers

PMID: 28422980
DOI: 10.1371/journal.pone.0175702
PMCID: PMC5397027

Genes

ABCB1

Provenance

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