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Article

Genome-wide patterns of nucleotide substitution reveal stringent functional constraints on the protein sequences of thermophiles.

Genetics - 1 Jul 2004

Friedman Robert, Drake John W, Hughes Austin L

Abstract excerpt

To test the hypothesis that the proteins of thermophilic prokaryotes are subject to unusually stringent functional constraints, we estimated the numbers of synonymous and nonsynonymous nucleotide substitutions per site between 17,957 pairs of orthologous genes from 22 pairs of closely related species of Archaea and Bacteria. The average ratio of nonsynonymous to synonymous substitutions was significantly lower in...

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Identifiers

PMID: 15280258
DOI: 10.1534/genetics.104.026344
PMCID: PMC1470942

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