Identifying the susceptibility gene(s) in a set of trait-linked genes using genotype data.

doi:10.1534/genetics.103.021600

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Article

Identifying the susceptibility gene(s) in a set of trait-linked genes using genotype data.

Genetics - 1 Jul 2004

Yuan Ao, Chen Guanjie, Chen Yuanxiu, Rotimi Charles, Bonney George E

Abstract excerpt

There are generally three steps to isolate a disease linkage-susceptibility gene: genome-wide scan, fine mapping, and, last, positional cloning. The last step is time consuming and involves intensive laboratory work. In some cases, fine mapping cannot proceed further on a set of markers because they are tightly linked. For years, genetic statisticians have been trying different ways to narrow the fine-mapping...

Topics

Chromosome Mapping
Genetic Predisposition to Disease
Genotype
Linkage Disequilibrium
Models, Genetic
Polymorphism, Single Nucleotide

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Identifiers

PMID: 15280254
DOI: 10.1534/genetics.103.021600
PMCID: PMC1470967

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