Article
Analysis of cytokine patterns produced by individual CD4+ lymph node cells during experimental murine leishmaniasis in resistant and susceptible mice.
International immunology - 1 Dec 1998
Sommer F, Meixner M, Mannherz M, Ogilvie A L, Röllinghoff M, Lohoff M
Abstract excerpt
The concept of subdividing CD4+ T cells into Th0, Th1 and Th2 cells is based on the cytokine pattern produced by long-term in vitro cultured T cell lines. However, there exists uncertainty whether this classification can also be applied to CD4+ T cells in vivo. Herein it was investigated whether...
Topics
- Animals
- Antigens, Protozoan
- CD4-Positive T-Lymphocytes
- Cell Line
- Cytokines
- Female
- Genetic Predisposition to Disease
- Immunity, Innate
- Immunologic Memory
- Interferon-gamma
- Interleukin-2
- Interleukin-4
- Leishmaniasis, Cutaneous
- Lymph Nodes
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mitogens