Article
Analysis of cytokine patterns produced by individual CD4+ lymph node cells during experimental murine leishmaniasis in resistant and susceptible mice.
International immunology - 1 Dec 1998
Sommer F, Meixner M, Mannherz M, Ogilvie A L, Röllinghoff M, Lohoff M
Abstract excerpt
The concept of subdividing CD4+ T cells into Th0, Th1 and Th2 cells is based on the cytokine pattern produced by long-term in vitro cultured T cell lines. However, there exists uncertainty whether this classification can also be applied to CD4+ T cells in vivo. Herein it was investigated whether and at which frequency Th0, Th1 and Th2 cells are induced in vivo during an infection of mice with Leishmania major....
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