Article
apg15-1, a UGA mutant allele in the Saccharomyces cerevisiae APG16 gene, and its suppression by a cytoplasmic factor.
Bioscience, biotechnology, and biochemistry - 1 Jul 2004
Okazaki Hiroshi, Ono Bun-Ichiro, Ohsumi Yoshinori, Ohsumi Mariko
Abstract excerpt
Autophagy is a complex cellular process by which starving cells utilize cytoplasmic macromolecules as nutritional resources. In Saccharomyces cerevisiae, more than 15 genes are involved in this process and most of them have been cloned and characterized by now. But there remains a complementation group represented by a single mutation, apg15-1, unclear as to its molecular nature. We obtained DNA fragments that...
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