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Article

Microphthalmia transcription factor induces both retinal pigmented epithelium and neural crest melanocytes from neuroretina cells.

The Journal of biological chemistry - 1 Oct 2004

Planque Nathalie, Raposo Graça, Leconte Laurence, Anezo Oceane, Martin Patrick, Saule Simon

Abstract excerpt

Mitf encodes a basic helix-loop-helix transcription factor that plays an essential role in the differentiation of the retinal pigmented epithelium (RPE) and neural crest-derived melanocytes. As cells containing melanogenic enzymes (TRP2) are found in Mitf mouse mutants, it is not clear whether Mitf is a downstream factor or a master regulator of melanocyte differentiation. To further study the role of Mitf in...

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Source

Identifiers

PMID: 15277526
DOI: 10.1074/jbc.M404964200

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Microphthalmia transcription factor induces both retinal pigmented epithelium and neural crest melanocytes from neuroretina cells.PMID 15277526Read ↗

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The Microphthalmia-Associated Transcription Factor (MITF) and Its Role in the Structure and Function of the Eye.Semantic proximity Read ↗

Microphthalmia-associated transcription factor (MITF): multiplicity in structure, function, and regulation.Semantic proximity Read ↗

Spontaneous transdifferentiation of quail pigmented epithelial cell is accompanied by a mutation in the Mitf gene.Semantic proximity Read ↗

Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently.Semantic proximity Read ↗

nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate.Semantic proximity Read ↗

Role of Mitf in Differentiation and Transdifferentiation of Chicken Pigmented Epithelial CellSemantic proximity Read ↗

Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice.Semantic proximity Read ↗

OTX2 activates the molecular network underlying retina pigment epithelium differentiation.Semantic proximity Read ↗

A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish.Semantic proximity Read ↗

“Transcription physiology” of pigment formation in melanocytes: central role of MITFSemantic proximity Read ↗

Modeling of pigmentation disorders associated with MITF mutation in Waardenburg syndrome revealed an impaired melanogenesis pathway in iPS-derived melanocytes.Semantic proximity Read ↗

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