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Article

A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish.

Development (Cambridge, England) - 1 Oct 2023

Miyadai Motohiro, Takada Hiroyuki, Shiraishi Akiko, Kimura Tetsuaki, Watakabe Ikuko, Kobayashi Hikaru, Nagao Yusuke, Naruse Kiyoshi, Higashijima Shin-Ichi, Shimizu Takashi, Kelsh Robert N, Hibi Masahiko, Hashimoto Hisashi

Abstract excerpt

Neural crest cells generate numerous derivatives, including pigment cells, and are a model for studying how fate specification from multipotent progenitors is controlled. In mammals, the core gene regulatory network for melanocytes (their only pigment cell type) contains three transcription factors, Sox10, Pax3 and Mitf, with the latter considered a master regulator of melanocyte development. In teleosts, which...

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Identifiers

PMID: 37823232
DOI: 10.1242/dev.202114
PMCID: PMC10617610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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