Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.

The Journal of clinical investigation - 1 Mar 2004

Iwanaga Yoshitaka, Hoshijima Masahiko, Gu Yusu, Iwatate Mitsuo, Dieterle Thomas, Ikeda Yasuhiro, Date Moto-o, Chrast Jacqueline, Matsuzaki Masunori, Peterson Kirk L, Chien Kenneth R, Ross John

Abstract excerpt

Ablation or inhibition of phospholamban (PLN) has favorable effects in several genetic murine dilated cardiomyopathies, and we showed previously that a pseudophosphorylated form of PLN mutant (S16EPLN) successfully prevented progressive heart failure in cardiomyopathic hamsters. In this study, the effects of PLN inhibition were examined in rats with heart failure after myocardial infarction (MI), a model of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dependovirus
Share to Echocardiography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Heart Ventricles

Share to Pressure

Share to Ventricular Dysfunction, Left

Share to Ventricular Function, Left

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 14991071
DOI: 10.1172/JCI18716
PMCID: PMC351313

Genes

PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.PMID 14991071Read ↗

Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery.Semantic proximity Read ↗

Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathySemantic proximity Read ↗

The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.Semantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and humanSemantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.Semantic proximity Read ↗

Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation.Semantic proximity Read ↗

Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model for Phospholamban R14del cardiomyopathySemantic proximity Read ↗

Phospholamban phosphorylation sites enhance the recovery of intracellular Ca2+ after perfusion arrest in isolated, perfused mouse heart.Semantic proximity Read ↗

Adenoviral gene transfer of mutant phospholamban rescues contractile dysfunction in failing rabbit myocytes with relatively preserved SERCA function.Semantic proximity Read ↗

Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport.Semantic proximity Read ↗

Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failureSemantic proximity Read ↗

Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.