Article
Generating MHC Class II+/Ii- phenotype after adenoviral delivery of both an expressible gene for MHC Class II inducer and an antisense Ii-RNA construct in tumor cells.
Gene therapy - 1 Aug 2003
Hillman G G, Kallinteris N L, Li J, Wang Y, Lu X, Li Y, Wu S, Wright J L, Slos P, Gulfo J V, Humphreys R E, Xu M
Abstract excerpt
Tumor cells engineered by gene transduction to be MHC Class II+/Ii- are novel APCs capable of presenting endogenous tumor antigen epitopes to activate T helper cells. The MHC Class II+/Ii- tumor cell phenotype is created by transfecting genes for either CIITA or IFN-gamma, and inhibiting induced Ii mRNA by an Ii reverse gene construct (Ii-RGC). Adenoviral vectors are preferred for the delivery of such genes...
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