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Article

Mutations in the lysyl oxidase gene not associated with intracranial aneurysm in central European families.

Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2004

Hofer Anne, Ozkan Süheyla, Hermans Marcella, Kubassek Nina, Sitzer Matthias, Burtscher Johannes, Knopp Ulrich, Schoch Beate, Wanke Isabel, Huebner Felix, Raabe Andreas, Steinmetz Helmuth, Auburger Georg

Abstract excerpt

BACKGROUND: Lysyl oxidase is a promising candidate gene for a mutation search in intracranial aneurysm families because (a) it controls the processing, cross-linking and maturation of collagen and elastin fibers in the blood vessel wall, (b) its expression levels and activity are altered in different animal models of aneurysm pathogenesis, and (c) it is encoded within the chromosome 5q22-31 region of suggestive...

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PMID: 15273433
DOI: 10.1159/000079940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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