Article
Sequence variations in the von Hippel-Lindau tumor suppressor gene in patients with intracranial aneurysms.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 May 2013
Klingler Jan-Helge, Krüger Marie T, Lemke Johannes R, Jilg Cordula, Van Velthoven Vera, Zentner Josef, Neumann Hartmut P H, Gläsker Sven
Abstract excerpt
BACKGROUND: The rupture of intracranial aneurysms leads to subarachnoid hemorrhage, which is often associated with poor outcome. Preventive treatment of unruptured intracranial aneurysms is possible and recommended. However, the lack of candidate genes precludes identifying patients at risk by genetic analyses. We observed intracranial aneurysms in 2 patients with von Hippel-Lindau (VHL) disease and the known...
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