Article
Lack of association of lysyl oxidase (LOX) gene polymorphisms with intracranial aneurysm in a south Indian population.
Molecular biology reports - 1 Oct 2013
Sathyan Sanish, Koshy Linda, Sarada Lekshmi K R, Easwer H V, Premkumar S, Alapatt Jacob P, Nair Suresh, Bhattacharya R N, Banerjee Moinak
Abstract excerpt
Intracranial aneurysm (IA) accounts for 85 % of haemorrhagic stroke and is mainly caused due to weakening of arterial wall. Lysyl oxidase (LOX) is a cuproenzyme involved in cross linking structural proteins collagen and elastin, thus providing structural stability to artery. Using a case-control study design, we tested the hypothesis whether the variants in LOX gene flanking the two LD block, can increase risk of...
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