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Article

Basolateral membrane expression of a K+ channel, Kir 2.3, is directed by a cytoplasmic COOH-terminal domain.

Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2001

Le Maout S, Welling P A, Brejon M, Olsen O, Merot J

Abstract excerpt

The inwardly rectifying potassium channel Kir 2.3 is specifically targeted and expressed on the basolateral membrane of certain renal epithelial cells. In the present study, the structural basis for polarized targeting was elucidated. Deletion of a unique COOH-terminal domain produced channels that were mistargeted to the apical membrane, consistent with the removal of a basolateral membrane-sorting signal. By...

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Identifiers

PMID: 11504929
DOI: 10.1073/pnas.181481098
PMCID: PMC56985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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