Article
An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells.
American journal of physiology. Renal physiology - 1 Jul 2010
Ito Mikiko, Sakurai Aya, Hayashi Keiji, Ohi Akiko, Kangawa Natsumi, Nishiyama Takashi, Sugino Sakiko, Uehata Yoko, Kamahara Akihiro, Sakata Masae, Tatsumi Sawako, Kuwahata Masashi, Taketani Yutaka, Segawa Hiroko, Miyamoto Ken-ichi
Abstract excerpt
The type IIc Na(+)-dependent phosphate cotransporter (NaPi-IIc) is specifically targeted to, and expressed on, the apical membrane of renal proximal tubular cells and mediates phosphate transport. In the present study, we investigated the signals that determine apical expression of NaPi-IIc with a focus on the role of the N- and the C-terminal tails of mouse NaPi-IIc in renal epithelial cells [opossum kidney (OK)...
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