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Article

Lack of Charge Interaction in the Ion Binding Site Determines Anion Selectivity in the Sodium Bicarbonate Cotransporter NBCe1.

International journal of molecular sciences - 4 Jan 2022

Lee Soojung, Lin Jason, Choi Inyeong

Abstract excerpt

The Na/HCO3 cotransporter NBCe1 is a member of SLC4A transporters that move HCO3- across cell membranes and regulate intracellular pH or transepithelial HCO3 transport. NBCe1 is highly selective to HCO3- and does not transport other anions; the molecular mechanism of anion selectivity is presently unclear. We previously reported that replacing Asp555 with a Glu (D555E) in NBCe1 induces increased selectivity to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35008963
DOI: 10.3390/ijms23010532
PMCID: PMC8745181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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