Article
A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study.
American journal of human genetics - 1 Sept 2004
Hauser Elizabeth R, Crossman David C, Granger Christopher B, Haines Jonathan L, Jones Christopher J H, Mooser Vincent, McAdam Brendan, Winkelmann Bernhard R, Wiseman Alan H, Muhlestein J Brent, Bartel Alan G, Dennis Charles A, Dowdy Elaine, Estabrooks Susan, Eggleston Karen, Francis Sheila, Roche Kath, Clevenger Paula W, Huang Liling, Pedersen Bonnie, Shah Svati, Schmidt Silke, Haynes Carol, West Sandra, Asper Donny, Booze Michael, Sharma Sanjay, Sundseth Scott, Middleton Lefkos, Roses Allen D, Hauser Michael A, Vance Jeffery M, Pericak-Vance Margaret A, Kraus William E
Abstract excerpt
A family history of coronary artery disease (CAD), especially when the disease occurs at a young age, is a potent risk factor for CAD. DNA collection in families in which two or more siblings are affected at an early age allows identification of genetic factors for CAD by linkage analysis. We performed a genomewide scan in 1,168 individuals from 438 families, including 493 affected sibling pairs with documented...
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