Article
Dopamine receptor D2 deficiency reduces mouse pup ultrasonic vocalizations and maternal responsiveness.
Genes, brain, and behavior - 1 Jun 2013
Curry T, Egeto P, Wang H, Podnos A, Wasserman D, Yeomans J
Abstract excerpt
Dopamine signalling facilitates motivated behaviours, and the D2 dopamine receptor (D2R) is important in mother-infant interactions. D2R antagonists disrupt maternal behaviour and, in isolated rat pups, reduce ultrasonic vocalizations (USVs) that promote maternal interaction. Here, we examined the effects of genetic D2R signalling deficiency on pup-dam interaction with Drd2 knockout (D2R KO) mice. Using...
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