Article
Loss of cell wall mannosylphosphate in Candida albicans does not influence macrophage recognition.
The Journal of biological chemistry - 17 Sept 2004
Hobson Richard P, Munro Carol A, Bates Steven, MacCallum Donna M, Cutler Jim E, Heinsbroek Sigrid E M, Brown Gordon D, Odds Frank C, Gow Neil A R
Abstract excerpt
The outer layer of the cell wall of the human pathogenic fungus Candida albicans is enriched with heavily mannosylated glycoproteins that are the immediate point of contact between the fungus and cells of the host, including phagocytes. Previous work had identified components of the acid-labile fraction of N-linked mannan, comprising beta-1,2-linked mannose residues attached via a phosphodiester bond, as...
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