Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans.

doi:10.1074/jbc.M510360200

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Article

Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans.

The Journal of biological chemistry - 6 Jan 2006

Bates Steven, Hughes H Bleddyn, Munro Carol A, Thomas William P H, MacCallum Donna M, Bertram Gwyneth, Atrih Abdelmadjid, Ferguson Michael A J, Brown Alistair J P, Odds Frank C, Gow Neil A R

Abstract excerpt

The outer layer of the Candida albicans cell wall is enriched in highly glycosylated mannoproteins that are the immediate point of contact with the host and strongly influence the host-fungal interaction. N-Glycans are the major form of mannoprotein modification and consist of a core structure, common to all eukaryotes, that is further elaborated in the Golgi to form the highly branched outer chain that is...

Topics

Candida albicans
Cell Wall
Epitopes
Glycosylation
Mannosyltransferases
Methylation
Mutation
Polysaccharides
Virulence

Source

Open in PubMed

Identifiers

PMID: 16263704
DOI: 10.1074/jbc.M510360200

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