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Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells

24 Jul 2004

Abstract excerpt

Gene expression profiles of bone marrow (BM) CD34-derived megakaryocytic cells (MKs) were compared in patients with essential thrombocythemia (ET) and healthy subjects using oligonucleotide microarray analysis to identify differentially expressed genes and disease-specific transcripts. We found that proapoptotic genes such as BAX, BNIP3, and BNIP3L were down-regulated in ET MKs together with genes that are...

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PMID: 15271793
DOI: 10.1182/blood-2003-07-2597

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